Interacting Effects of Sulfonylureas and Glucose
نویسندگان
چکیده
Part of this work was previously reported at the symposium "Diabetes Research Today," held in Capri, Italy, 13-15 April 1976, and published in Symposia Medica Hoechst 12, 223240 (1976), Friedrich-Karl Schattauer-Verlag GmbH, Stuttgart, West Germany. Dr. Cerasi's present address is the Department of Endocrinology and Metabolism, the Hebrew University Hadassah Medical School, Jerusalem, Israel. Received for publication 25 July 1977 and in revised form 8 November 1977. hibited both the glucose and the sulfonylurea [3H]cyclic AMP and insulin responses. Epinephrine (1 uM) partially inhibited the [3H]cyclic AMP response to both glucose and sulfonylurea, whereas insulin release was completely abolished. It is concluded that the sulfonylurea effects on islet cyclic AMP are intimately related to those of glucose. It is suggested that sulfonylureas exert a major part of their action by facilitating the effect of glucose on the beta-cell adenylate cyclase; the increased cyclic AMP level, in its turn, enhances the secretion rate of insulin.
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